Intestinal Secretion Induced by Vasoactive Intestinal Polypeptide
作者： Guenter J. Krejs , Ronald M. Barkley , Nicholas W. Read , John S. Fordtran
DOI: 10.1172/JCI109051
关键词:
摘要: A B S T RA C The effect ofvasoactive intestinal polypeptide (VIP) on water and electrolyte transport transmucosal potential difference was investigated in the dog jejunum vivo compared to secretion induced by cholera toxin. Isolated jejunal loops were perfused with a plasma-like solution. VIP (0.08 ug/kg per min) administered directly into superior mesenteric artery continuous infusion over 1 h. From dye dilution method, it estimated that mean plasma concentration of 12,460 pglml reached loops. caused electrolytes; for example, chloride: control, 8 ,ueq/cm h absorption; VIP, 92 ,eq/ cm secretion. marked increase (control, -1.0 mV; -5.9 mV, lumen negative) occurred within min after starting infusion. Analysis unidirectional fluxes showed increased plasma-to-lumen flux ofsodium chloride decreased lumen-to-plasma sodium. Chloride bicarbonate actively secreted against an electrochemical gradient. Although sodium down gradient, ratio analysis suggested component active slight protein output loops; light microscopy revealed capillary dilatation closed intercellular spaces. readily reversible. Except delayed onset secretion, toxin qualitatively similar VIP; however, not noted
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