Activation of cerebral guanylate cyclase by nitric oxide.

作者: Naomasa Miki , Yasunori Kawabe , Kinya Kuriyama

DOI: 10.1016/0006-291X(77)91460-7

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摘要: Mouse cerebral guanylate cyclase was activated by catalase in the presence of sodium azide (NaN/sub 3/), which is known to form catalase-NO complex, while nitrosamines and nitric oxide (NO gas) were capable activating absence catalase. The activation NaN/sub 3/-catalase or markedly inhibited ferrohemoglobin has a high affinity for NO, but not ferrihemoglobin. These data suggest that NO containing compounds may activate cyclase, whereas exhibit an inhibitory effect on possibly interacting with compounds.

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