Preparation and Characterization of Solid Dispersions of Artemether by Freeze-Dried Method
作者： Muhammad Tayyab Ansari , Altaf Hussain , Sumaira Nadeem , Humaira Majeed , Syed Saeed-Ul-Hassan
DOI: 10.1155/2015/109563
关键词:
摘要: Solid dispersions of artemether and polyethylene glycol 6000 (PEG6000) were prepared in ratio 12 : 88 (group-1). Self-emulsified solid by using 6000, Cremophor-A25, olive oil, Transcutol, hydroxypropyl methylcellulose (HPMC) 12 : 75 : 5 : 4 : 2 : 2, respectively (group-2). In third group, only Cremophor-A25 was replaced with Poloxamer 188 compared to group-2. The self-emulsified physical freeze dried methods, respectively. All samples characterized X-ray diffraction, attenuated total reflectance Fourier transform infrared spectroscopy, differential scanning calorimeter, electron microscopy, solubility, dissolution, stability studies. diffraction pattern revealed complete crystalline, whereas mixture freeze-dried all three groups showed reduced peak intensities. spectroscopy spectra, C–H stretching vibrations masked samples, while representative 188. Differential calorimetry decreased melting endotherm increased enthalpy change () both mixtures groups. Scanning microscopy glassy appearance, size reduction, embedment, their reduction embedment excipients. group-1, solubility improved up 15 times, group-2 121 times increase but, group-3, when used instead 135 times. fasted state simulated gastric fluid at pH 1.6, the dissolution 12 substantially enhanced Hank’s balanced salt solution 7.4.
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Dimitrios Bikiaris, George Z. Papageorgiou, Anagnostis Stergiou, Eleni Pavlidou, Evangelos Karavas, Ferras Kanaze, Manolis Georgarakis, Physicochemical studies on solid dispersions of poorly water-soluble drugs: Evaluation of capabilities and limitations of thermal analysis techniques Thermochimica Acta. ,vol. 439, pp. 58- 67 ,(2005) , 10.1016/J.TCA.2005.09.011
Mahmood Ahmad, Haji M. S. Khan, Fatima Rasool, Ghulam Murtaza, Shujaat A. Khan, Metoprolol tartrate-ethylcellulose tabletted microparticles: formulation and in vitro evaluation Latin American Journal of Pharmacy. ,(2010)
Gilbert Lefèvre, Margaretha Bindschedler, Farkad Ezzet, Nicole Schaeffer, Ingo Meyer, Mikael S Thomsen, Pharmacokinetic interaction trial between co-artemether and mefloquine. European Journal of Pharmaceutical Sciences. ,vol. 10, pp. 141- 151 ,(2000) , 10.1016/S0928-0987(00)00060-9
G Betageri, Enhancement of dissolution of glyburide by solid dispersion and lyophilization techniques International Journal of Pharmaceutics. ,vol. 126, pp. 155- 160 ,(1995) , 10.1016/0378-5173(95)04114-1
M. Guyot, F. Fawaz, J. Bildet, F. Bonini, A.-M. Lagueny, Physicochemical characterization and dissolution of norfloxacin/cyclodextrin inclusion compounds and PEG solid dispersions International Journal of Pharmaceutics. ,vol. 123, pp. 53- 63 ,(1995) , 10.1016/0378-5173(95)00039-L
Anshuman A Ambike, KR Mahadik, Anant Paradkar, None, Stability study of amorphous valdecoxib. International Journal of Pharmaceutics. ,vol. 282, pp. 151- 162 ,(2004) , 10.1016/J.IJPHARM.2004.06.009
C.M McLoughlin, W.A.M McMinn, T.R.A Magee, Physical and dielectric properties of pharmaceutical powders Powder Technology. ,vol. 134, pp. 40- 51 ,(2003) , 10.1016/S0032-5910(03)00133-5
Francesco Castelli, Silvia Odolini, Beatrice Autino, Emanuele Foca, Rosario Russo, Malaria Prophylaxis: A Comprehensive Review Pharmaceuticals. ,vol. 3, pp. 3212- 3239 ,(2010) , 10.3390/PH3103212
Long-Hu Wang, Yan-Ting Song, Yong Chen, Yi-Yu Cheng, Solubility of Artemisinin in Ethanol + Water from (278.2 to 343.2) K Journal of Chemical & Engineering Data. ,vol. 52, pp. 757- 758 ,(2007) , 10.1021/JE0603426
Dan Wang, Haiyan Li, Jingkai Gu, Tao Guo, Shuo Yang, Zhen Guo, Xueju Zhang, Weifeng Zhu, Jiwen Zhang, Ternary system of dihydroartemisinin with hydroxypropyl-β-cyclodextrin and lecithin: Simultaneous enhancement of drug solubility and stability in aqueous solutions Journal of Pharmaceutical and Biomedical Analysis. ,vol. 83, pp. 141- 148 ,(2013) , 10.1016/J.JPBA.2013.05.001