Hilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes, and development-related molecules.

摘要: Embryologically, intrahepatic small bile ducts arise from hepatic progenitor cells via ductal plates, whereas the pancreato-extrahepatic biliary expressing transcription factors PDX1 and HES1 are reportedly involved in development of extrahepatic tract ventral pancreas. The expression cellular markers characteristic different anatomical levels tree pancreas, as well HES1, was examined cholangiocarcinoma components combined hepatocellular (12 cases), (21 hilar (25 pancreatic adenocarcinoma (18 cases). Anterior gradient protein-2 S100P were frequently expressed adenocarcinoma, neural cell adhesion molecule luminal epithelial membrane antigen common cholangiocarcinoma. markedly and, to a lesser degree, cholangiocarcinoma, although their rare mild patterns these molecules intermediate between those Pancreatic had similar mucin, immunophenotypes, factors. showed postoperative prognosis. In conclusion, phenotypes related pancreatobiliary anatomy embryology may part explain why 2 types carcinoma present clinicopathologic features. Further studies on carcinogenesis carcinomas based similarities warranted.