CD36 is a co-receptor for hepatitis C virus E1 protein attachment
作者： Jun-Jun Cheng , Jian-Rui Li , Meng-Hao Huang , Lin-Lin Ma , Zhou-Yi Wu
DOI: 10.1038/SREP21808
关键词:
摘要: The cluster of differentiation 36 (CD36) is a membrane protein related to lipid metabolism. We show that HCV infection in vitro increased CD36 expression either surface or soluble form. attachment was facilitated through direct interaction between and E1 protein, causing enhanced entry replication. co-receptor effect independent SR-BI. monoclonal antibodies neutralized the reduced inhibitor sulfo-N-succinimidyl oleate (SSO), which directly bound but not SR-BI, significantly interrupted entry, therefore inhibited SSO’s antiviral seen only other viruses. SSO combination with known anti-HCV drugs showed additional inhibition against HCV. considerably safe mice. Conclusively, interacts might be specific for entry; thus, could potential drug target
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