The action of apamin on guinea-pig taenia caeci

摘要: Abstract Apamin (10 −7 M), a substance extracted from bee venom ( apis mellifica ) causes stimulation of the taenia caeci as seen an increase in spike activity. The inhibitory effect ATP or adrenaline (Adr) was reflected by hyperpolarization muscle cell, cessation activity and relaxation muscle. 42 K efflux membrane conductance were enhanced presence these substances. Apamine converted caused Adr into transient depolarization which produced contraction cells. changes diminished toxin. Furthermore, potassium-dependent phase action potential lengthened apamine. Reduction extracellular chloride sodium concentration, blockade nervous system TTX (3 × 10 M) inhibition D600 −6 did not affect excitatory blocking apamin. A high concentration calcium antagonist −4 omission needed to reduce evoked It is concluded that apamin prevents opening ATP- Adr-sensitive voltage-dependent potassium channels guinea-pig caeci.