Chemotherapy of human malignant glioma : Prevention of efficacy by dexamethasone?

摘要: Steroids are commonly administered for the control of edema, mass effect, and side effects from therapy to patients with malignant glioma who receiving radiotherapy chemotherapy. Here, we report that therapeutic concentrations dexamethasone (DEX) attenuate cytotoxicity growth inhibition human cells induced by exposure several chemotherapeutics, including ACNU, VM-26, vincristine, cytarabine, metho-trexate, adriamycin. DEX-mediated cytoprotection is not linked DEX on cell proliferation. However, cytoprotective appeared be more prominent in lines wild-type p53 status (n = 2) than mutant 3). Further, rescue chemotherapy does directly involve Bcl-2 family proteins since failed change expression or Bax bcl-2 gene transfer-mediated was redundant DEX. thus appears a common, bcl-2-independent death pathway limited specific drug actions. Chemotherapy usually given as an elective, adjuvant treatment stable condition can tolerate steroid withdrawal. To maximize I efficacy, steroids should withdrawn prior