Leukocyte subsets and neutrophil function after short-term spaceflight.

摘要: Changes in leukocyte subpopulations and function after spaceflight have been observed but the mechanisms underlying these changes are not well defined. This study investigated effects of short-term (8-15 days) on circulating subsets, stress hormones, immunoglobulin levels, neutrophil function. At landing, a 1.5-fold increase neutrophils was compared with preflight values; lymphocytes were slightly decreased, whereas results variable for monocytes. No significant plasma levels immunoglobulins, cortisol, or adrenocorticotropic hormone. In contrast, urinary epinephrine, norepinephrine, cortisol significantly elevated at landing. Band 9 16 astronauts. Neutrophil chemotactic assays showed 10-fold decrease optimal dose response adhesion to endothelial cells increased both before spaceflight. expression MAC-1 decreased while L-selectin increased. These functional alterations may be clinical significance long-duration space missions.