The Rocky Road From Fed-Batch to Continuous Processing With E. coli.

作者: Julian Kopp , Christoph Slouka , Oliver Spadiut , Christoph Herwig

DOI: 10.3389/FBIOE.2019.00328

关键词:

摘要: Escherichia coli still serves as a beloved workhorse for the production of many biopharmaceuticals as it fulfills essential criteria, such as having fast doubling times, exhibiting a low risk …

参考文章(203)
K. Plumb, Continuous Processing in the Pharmaceutical Industry: Changing the Mind Set Chemical Engineering Research & Design. ,vol. 83, pp. 730- 738 ,(2005) , 10.1205/CHERD.04359
Andreas Schmideder, Timm Steffen Severin, Johannes Heinrich Cremer, Dirk Weuster-Botz, A novel milliliter-scale chemostat system for parallel cultivation of microorganisms in stirred-tank bioreactors. Journal of Biotechnology. ,vol. 210, pp. 19- 24 ,(2015) , 10.1016/J.JBIOTEC.2015.06.402
Orawan Borirak, Matthew D. Rolfe, Leo J. de Koning, Huub C.J. Hoefsloot, Martijn Bekker, Henk L. Dekker, Winfried Roseboom, Jeffrey Green, Chris G. de Koster, Klaas J. Hellingwerf, Time-series analysis of the transcriptome and proteome of Escherichia coli upon glucose repression. Biochimica et Biophysica Acta. ,vol. 1854, pp. 1269- 1279 ,(2015) , 10.1016/J.BBAPAP.2015.05.017
Andrew L Zydney, Perspectives on integrated continuous bioprocessing—opportunities and challenges Current Opinion in Chemical Engineering. ,vol. 10, pp. 8- 13 ,(2015) , 10.1016/J.COCHE.2015.07.005
Diethard Mattanovich, Paola Branduardi, Laura Dato, Brigitte Gasser, Michael Sauer, Danilo Porro, Recombinant Protein Production in Yeasts Recombinant Gene Expression. ,vol. 824, pp. 329- 358 ,(2012) , 10.1007/978-1-61779-433-9_17
Beatrix Fahnert, Hauke Lilie, Peter Neubauer, Inclusion Bodies: Formation and Utilisation Physiological Stress Responses in Bioprocesses. ,vol. 89, pp. 93- 142 ,(2004) , 10.1007/B93995
Jonathan Baert, Romain Kinet, Alison Brognaux, Anissa Delepierre, Samuel Telek, Søren J. Sørensen, Leise Riber, Patrick Fickers, Frank Delvigne, Phenotypic variability in bioprocessing conditions can be tracked on the basis of on-line flow cytometry and fits to a scaling law Biotechnology Journal. ,vol. 10, pp. 1316- 1325 ,(2015) , 10.1002/BIOT.201400537
Christoph Herwig, Oscar F. Garcia-Aponte, Aydin Golabgir, Anurag S. Rathore, Knowledge management in the QbD paradigm: manufacturing of biotech therapeutics. Trends in Biotechnology. ,vol. 33, pp. 381- 387 ,(2015) , 10.1016/J.TIBTECH.2015.04.004
F. William Studier, Alan H. Rosenberg, John J. Dunn, John W. Dubendorff, Use of T7 RNA polymerase to direct expression of cloned genes. Methods in Enzymology. ,vol. 185, pp. 60- 89 ,(1990) , 10.1016/0076-6879(90)85008-C