The association between familial death in childhood or adolescence and subsequent substance use disorder: A systematic review and meta-analysis.

摘要: BACKGROUND Exposure to childhood adversity has been linked long-term negative mental health consequences in adulthood. PURPOSE This review examined the association between exposure death of a family member (i.e., parent or sibling) during adolescence and subsequent diagnosis substance use disorder. METHODS Electronic databases (Scopus, Medline (for Ovid), EMBASE, PsychINFO) were searched for cohort case-control studies English language. Studies retained if it was demonstrable that occurred before age 18, disorder diagnosed subsequently. Sensitivity analyses performed meta-analysis, study quality assessed using Newcastle-Ottawa Scale. RESULTS Nine studies, seven two case-control, retained. Due differential metrics (hazard ratios [HRs] versus odds/risk [ORs/RRs]), only one meta-analysis possible. Individuals experiencing familial had 1.42 (95% CI = 0.96, 2.09) times odds developing compared those non-exposed. Where there statistically significant effect other these mostly National Registers (1.4 ≤ HR ≤ 2.51). LIMITATIONS Meta-analysis options limited by variety designs. CONCLUSIONS Evidence appears be an artefact design. Implications key findings. Further are required better understand estimate disorders. Registration funding. The pre-registered (PROSPERO Reg No: CRD42020192892) funded Irish Research Council (COALESCE/2019/61).