Mitochondrial dysfunction and alterations of brain HMPAO SPECT in depressive disorder : perspectives on origins of "somatization"

摘要: Gardner, A. 2004. Mitochondrial dysfunction and alterations of brain HMPAO SPECT in depressive disorder perspectives on origins somatization . Karolinska Institutet at University Hospital Huddinge, Neurotec Institution, Division Psychiatry, SE-141 86 Stockholm A range somatic symptoms are more common patients with major depression than the general population. Similar have been described mitochondrial disorders, which decreased production adenosine triphosphate (ATP) is found. The aim present thesis was to investigate functions, regional distribution radiotracer 3-dimensional interpretation, results Scales Personality (KSP) chronic symptoms. Relationships between measures were explored. based six papers: I. ATP other investigations including DNA (mtDNA) studies muscle analyzed 28 patients, whom 21 filled KSP. II. Case history situ-hybridization mtDNA one patient from study III. biopsy, KSP another IV. by 84 patients. follow-up rating after 3.5 years obtained 65 Comparisons performed depressed primary care. V. 27 18 without tinnitus. VI. activity succinate-cytochrome c reductase (SCR, enzyme complex II + III respiratory chain) 20 unmedicated psychiatric 16 four schizophrenia. Significantly lower chain ratios, increased prevalence deleted mtDNA, found a group comparisons healthy controls. Low correlated high scores for Psychiatric first overt disease presentation two also presented individually. Deleted phenotypic expression rearrangements blood muscle. Stable significantly large compared Significant differences tinnitus non-tinnitus some regions previously be involved perception. relationships SCR associative sensory disorders indicate that functions may contribute these disorders. Biological could demonstrated using novel investigatory methods. biological symptom presentation. Various proposed reflecting psychological mechanism rather abnormality. depression, least when associated symptoms, systemic disturbance level cell organelle, entail different perspective etiology