Optimization of Light and Melatonin to Phase-Shift Human Circadian Rhythms

作者: D. J. Skene

DOI: 10.1046/J.1365-2826.2003.01006.X

关键词:

摘要: Both light and melatonin, appropriately timed, have been shown to phase-shift human circadian rhythms. In addition, both melatonin acute physiological behavioural effects. Depending on the dose, can reduce core body temperature induce sleepiness. Conversely, at night increases enhances alertness performance. The phase-shifting effects of justified their investigation use in treatment rhythm sleep disorders. Melatonin is choice for blind people with non-24 h sleep/wake disorder. Current research directed towards optimizing these therapies respect time administration, dose formulation intensity, duration spectral composition light. Our studies totally disorder that, addition improving sleep, daily administration entrain free-running ability rhythms depends, part, relative subject's phase. Subjects who were entrained by began phase advance portion (CT 6-18) published phase-response curves (PRCs), whereas those failed delay PRC. Whether effect axis be optimized altering its has investigated. Recently, it was demonstrated that light-induced suppression humans sensitive short wavelength (420-480 nm; λ max approximately 460 nm), a response very different classical scotopic photopic visual systems. other nonvisual responses (e.g. resetting) show similar sensitivity currently being studied.

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