Oncogenes associated with drug resistance in ovarian cancer

摘要: Oncogenes play pivotal roles in the development of cancer, and disturbances their expression have been implicated drug resistance. However, an overview contribution oncogenes to resistance ovarian cancer has not previously reported. This study aimed review resistance-related precisely determine relationships. The associated with from available papers were summarized, a comprehensive bioinformatics analysis including pathway enrichment, biological processes annotation, protein/gene interaction microRNA–mRNA was performed. Total 25 contributing integrated further analyzed. An oncogene-mediated that explains associations 21 these drafted on basis published papers. downstream location v-akt murine thymoma viral oncogene (AKT) B-cell CLL/lymphoma 2-associated X protein (BAX) respect many other determined, indicating two genes may central role, AKT- BAX-mediated signaling are main pathways accounting for involvement cancer. Besides, annotation process indicated apoptosis (cell death) phosphorylation (phosphate metabolic process) might be major routes through which contribute In addition, interactions, 11 microRNAs identified targeted at least 7 oncogenes, those could important regulator oncogenes. Collectively, by integrating analyzing data this contributes improving our understanding mechanisms leads