Dietary Patterns Are Associated with Hyperhomocysteinemia in an Urban Pakistani Population

摘要: Little attention has been given to the association of dietary patterns with plasma homocysteine. Our objective in this study was identify major and investigate their In a cross-sectional survey, 872 healthy adults (355 males, 517 females; aged 18-60 y) were enrolled from an urban population Karachi. Dietary intake assessed by FFQ. We used factor analysis define patterns. Fasting concentrations or serum homocysteine, folate, pyridoxal-phosphate (PLP; coenzyme form vitamin B-6), B-12 measured. Three identified labeled as "prudent diet," "high animal-protein plant-protein diet." observed protective effect prudent pattern for highest quartile compared lowest hyperhomocysteinemia when model adjusted age, gender, household income, BMI, tobacco chewing, smoking [OR = 0.52 (95% CI 0.30-0.90); P 0.01]. The high diet inversely related hyperhomocysteinemia, higher being protective. Compared 1st quartile, OR 0.42 0.25-0.69; 0.001) 4th quartile. positively associated participants having greatest increase risk 2.10 1.22-3.60); 0.007]. Plasma homocysteine appeared be correlated more circulating folate (r -0.25; < than PLP -0.02; 0.663) -0.16; 0.001). A rich fruits uncooked vegetables decreased whereas diets red meat, chicken, tea milk hyperhomocysteinemia.