Novel Therapeutics for Therapy-Related Acute Myeloid Leukemia: 2014

摘要: Effective treatment options for adults with therapy-related AML continues to be an area of unmet need. Genetic and molecular changes within these leukemias confer resitance standard chemotherapy regimens. Emerging develpmental therapeutics in this has focused on several approaches. These include; novel delivery as well newer DNA-damaging agents delivered through antibody-drug conjugates, increased use hypomethylating agents, molecularly-directed small molecules against specific mutations commonly occuring secondary AML. Results efforts are encouraging, but date, no clear improvements have been demonstrated most difficult treat population.