Effects of O2 on the reactions of activated bleomycin.
作者： R M Burger , J Peisach , S B Horwitz
DOI: 10.1016/S0021-9258(18)34784-7
关键词:
摘要: The antitumor drug, bleomycin, interacts with either Fe(II) and O 2 or Fe(III) H2O2 to form an activated complex which attacks DNA. Under aerobic conditions, both reactions yield similar quantities of free bases products consisting base plus deoxyribose carbon atoms 1 3. anaerobic bleomycin releases only base. is the same under provided DNA furnished in excess. When concentration limiting, more released than conditions. Drug self-destruction proceeds as quickly completely presence absence O2.
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