CAR T-cell therapy of solid tumors.

作者: Carmen S M Yong , Valerie Dardalhon , Christel Devaud , Naomi Taylor , Phillip K Darcy

DOI: 10.1038/ICB.2016.128

关键词:

摘要: … PD-1-CD28 CAR T cells showed similar efficacy to that of CAR T cells, suggesting the addition of another signaling domain can further augment CAR T-cell function. This holds promise …

参考文章(64)
Jonathan D. Powell, Greg M. Delgoffe, The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism Immunity. ,vol. 33, pp. 301- 311 ,(2010) , 10.1016/J.IMMUNI.2010.09.002
Michael H. Kershaw, Jennifer A. Westwood, Linda L. Parker, Gang Wang, Zelig Eshhar, Sharon A. Mavroukakis, Donald E. White, John R. Wunderlich, Silvana Canevari, Linda Rogers-Freezer, Clara C. Chen, James C. Yang, Steven A. Rosenberg, Patrick Hwu, A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer Clinical Cancer Research. ,vol. 12, pp. 6106- 6115 ,(2006) , 10.1158/1078-0432.CCR-06-1183
Dhanalakshmi Chinnasamy, Eric Tran, Zhiya Yu, Richard A. Morgan, Nicholas P. Restifo, Steven A. Rosenberg, Simultaneous Targeting of Tumor Antigens and the Tumor Vasculature Using T Lymphocyte Transfer Synergize to Induce Regression of Established Tumors in Mice Cancer Research. ,vol. 73, pp. 3371- 3380 ,(2013) , 10.1158/0008-5472.CAN-12-3913
Raffaella Bonecchi, Massimo Locati, Alberto Mantovani, Chemokines and Cancer: A Fatal Attraction Cancer Cell. ,vol. 19, pp. 434- 435 ,(2011) , 10.1016/J.CCR.2011.03.017
Daniel F. Legler, Caroline Johnson-Léger, Guido Wiedle, Claude Bron, Beat A. Imhof, The alpha v beta 3 integrin as a tumor homing ligand for lymphocytes. European Journal of Immunology. ,vol. 34, pp. 1608- 1616 ,(2004) , 10.1002/EJI.200424938
Nobuhiro Nishio, Iulia Diaconu, Hao Liu, Vincenzo Cerullo, Ignazio Caruana, Valentina Hoyos, Lisa Bouchier-Hayes, Barbara Savoldo, Gianpietro Dotti, Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor–Modified T Cells in Solid Tumors Cancer Research. ,vol. 74, pp. 5195- 5205 ,(2014) , 10.1158/0008-5472.CAN-14-0697
Ignazio Caruana, Barbara Savoldo, Valentina Hoyos, Gerrit Weber, Hao Liu, Eugene S Kim, Michael M Ittmann, Dario Marchetti, Gianpietro Dotti, Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T-lymphocytes Nature Medicine. ,vol. 21, pp. 524- 529 ,(2015) , 10.1038/NM.3833
Luca Gattinoni, Xiao-Song Zhong, Douglas C Palmer, Yun Ji, Christian S Hinrichs, Zhiya Yu, Claudia Wrzesinski, Andrea Boni, Lydie Cassard, Lindsay M Garvin, Chrystal M Paulos, Pawel Muranski, Nicholas P Restifo, Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells Nature Medicine. ,vol. 15, pp. 808- 813 ,(2009) , 10.1038/NM.1982
Antonio Di Stasi, Biagio De Angelis, Cliona M. Rooney, Lan Zhang, Aruna Mahendravada, Aaron E. Foster, Helen E. Heslop, Malcolm K. Brenner, Gianpietro Dotti, Barbara Savoldo, T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model. Blood. ,vol. 113, pp. 6392- 6402 ,(2009) , 10.1182/BLOOD-2009-03-209650
Michael H. Kershaw, Gang Wang, Jennifer A. Westwood, Russell K. Pachynski, H. Lee Tiffany, Francesco M. Marincola, Ena Wang, Howard A. Young, Philip M. Murphy, Patrick Hwu, Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2. Human Gene Therapy. ,vol. 13, pp. 1971- 1980 ,(2002) , 10.1089/10430340260355374