The molecular pathogenesis of pituitary tumors: implications for clinical management.

摘要: Pituitary adenomas are unique in several ways, and while they rarely malignant may be invasive and/or recurrent. Several attempts have been made to determine the growth potential of pituitary adenomas. tumors predominantly arise a sporadic setting or more as part hereditary genetic syndromes. Molecular analysis these familial has provided significant insight into tumorigenesis. Some specific genes identified that predispose neoplasia, but involved pathogenesis tumors. The number molecular alterations tumorigenesis is progressively increasing, providing hope for development new predictive prognostic markers. aim this review focus on pathology context their implications management targeted therapy. We summarized our current knowledge biology adenomas, we subsequently factors well markers promising therapies.