Sex Moderates the Impact of Diagnosis and Amyloid PET Positivity on Hippocampal Subfield Volume.
作者： Jessica Z.K. Caldwell , Jody-Lynn Berg , Guogen Shan , Jeffrey L. Cummings , Sarah J. Banks
DOI: 10.3233/JAD-180028
关键词:
摘要: We examined moderation effects of sex and diagnosis on the effect positive florbetapir positron emission tomography (PET) amyloid-β (Aβ) scan (A+) hippocampus subfield volumes in 526 normal control (NC) early mild cognitive impairment (eMCI) participants from Alzheimer's Disease Neuroimaging Initiative (ADNI2; ADNI-GO). Regression models showed that women- but not men- with NC designation did show reduced subiculum despite A+. At eMCI stage, A+ was detrimental across sexes. Findings were significant while accounting for age, cognition at screening, education, APOE4 carrier status. These findings suggest women have neural resistance to disease-related amyloid burden.
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