Inflammation-associated miR-155 activates differentiation of muscular satellite cells.

摘要: Tissue renewal and muscle regeneration largely rely on the proliferation differentiation of stem cells called muscular satellite (MuSCs). MuSCs are normally quiescent, but they activated in response to various stimuli, such as inflammation. Activated proliferate, migrate, differentiate, fuse form multinucleate myofibers. Meanwhile, inappropriate cues for MuSC activation induce premature bring about cell loss. Recent studies revealed that regulation is disrupted aged tissues. We found expression microRNA (miR)-155, which an inflammation-associated miR, upregulated muscles, this upregulation activates process through suppression C/ebpβ, important molecule maintaining self-renewal. also Notch1 considerably repressed miR-155 expression, loss induced overexpression. Our findings suggest can act activator might be responsible accelerating aging-associated MuSCs.