Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance.

摘要: Insulin resistance is a major disorder that links obesity to type 2 diabetes mellitus (T2D). It involves defects in the insulin actions owing reduced ability of trigger key signaling pathways metabolic tissues. The pathogenesis several inhibitory molecules interfere with tyrosine phosphorylation receptor and its downstream effectors. Among those, growing interest has been developed toward protein phosphatases (PTPs), large family enzymes can inactivate crucial effectors cascade by dephosphorylating their residues. Herein we briefly review role PTPs have shown be implicated regulation action, then focus on Src homology (SH2) domain-containing SHP1 SHP2 enzymes, since recent reports indicated roles for these control action glucose metabolism. Finally, therapeutic potential targeting combating alleviating T2D will discussed.