A Nonhuman Primate Model of Gilbert's Syndrome
作者： Oscar W. Portman , Jayanta Roy Chowdhury , Namita Roy Chowdhury , Manfred Alexander , Charles E. Cornelius
关键词:
摘要: A Bolivian population of squirrel monkeys, Saimiri sciureus, exhibits several features Gilbert's syndrome in man, and is proposed as a nonhuman primate model the condition. The was found to have higher fasting (40.6 ± 2.7 μM; mean S.E.) postcibal (9.9 0.9 μM) plasma unconjugated bilirubin concentrations (p < 0.001) than closely related Brazilian (fasting 5.5 0.7 μM); (2.4 μM). After intravenous administration [3H]bilirubin tracer dose or at 3.4 μmoles per kg body weight, there delayed clearance monkeys. Hepatic UDP-glucuronyl transferase activity for (164 25 nmoles 30 min gm liver) biliary diglucuronide monoglucuronide ratios (2.9 0.2) were lower monkeys Brazilians (421 36 liver-p 0.01 4.1 0.1–p 0.02, respectively). cytosol glutathione-S-transferase B (ligandin) levels similar two populations. phenobarbital therapy, (11.1 (5.3 1 significantly reduced 0.001). Sulfobromophthalein slightly slower SGOT, lactate dehydrogenase, -γ-glutamyl transpeptidase alkaline phosphatase activities not increased Bolivians. Fasting serum conjugated bile salt that 0.01). Erythrocyte survival hematological measurements comparable both
elsevier.com
sci-hub.se 参考文章(37)
J.G. Spenney, B.J. Johnson, B.I. Hirschowitz, A.A. Minas, R. Gibson, An 125I Radioimmunoassay for Primary Conjugated Bile Salts Gastroenterology. ,vol. 72, pp. 305- 311 ,(1977) , 10.1016/S0016-5085(77)80092-9
I Listowsky, I M Arias, M M Bhargava, Ligandin. Bilirubin binding and glutathione-S-transferase activity are independent processes. Journal of Biological Chemistry. ,vol. 253, pp. 4112- 4115 ,(1978) , 10.1016/S0021-9258(17)34690-2
Aldo Roda, Enrico Roda, Claudia Sama, Davide Festi, Rita Aldini, Antonio M. Morselli, Giuseppe Mazzella, Luigi Barbara, Serum primary bile acids in Gilbert's syndrome Gastroenterology. ,vol. 82, pp. 77- 83 ,(1982) , 10.1016/0016-5085(82)90126-3
A W Wolkoff, C A Goresky, J Sellin, Z Gatmaitan, I M Arias, Role of ligandin in transfer of bilirubin from plasma into liver. American Journal of Physiology-endocrinology and Metabolism. ,vol. 236, ,(1979) , 10.1152/AJPENDO.1979.236.6.E638
J Dawson, D L Carr-Locke, I C Talbot, F D Rosenthal, Gilbert's syndrome: evidence of morphological heterogeneity. Gut. ,vol. 20, pp. 848- 853 ,(1979) , 10.1136/GUT.20.10.848
I. M. ARIAS, I. M. LONDON, Bilirubin glucuronide formation in vitro; demonstration of a defect in Gilbert's disease. Science. ,vol. 126, pp. 563- 564 ,(1957) , 10.1126/SCIENCE.126.3273.563
Peter L.M. Jansen, beta-Glucuronidase-resistant bilirubin glucuronide isomers in cholestatic liver disease--determination of bilirubin metabolites in serum by means of high-pressure liquid chromatography. Clinica Chimica Acta. ,vol. 110, pp. 309- 317 ,(1981) , 10.1016/0009-8981(81)90360-0
Juerg Reichen, Familial unconjugated hyperbilirubinemia syndromes. Seminars in Liver Disease. ,vol. 3, pp. 24- 35 ,(1983) , 10.1055/S-2008-1040668
Martin Black, Sheila Sherlock, TREATMENT OF GILBERT'S SYNDROME WITH PHENOBARBITONE The Lancet. ,vol. 295, pp. 1359- 1362 ,(1970) , 10.1016/S0140-6736(70)91269-9
Martin Black, Barbara H. Billing, Hepatic Bilirubin UDP-Glucuronyl Transferase Activity in Liver Disease and Gilbert's Syndrome New England Journal of Medicine. ,vol. 280, pp. 1266- 1271 ,(1969) , 10.1056/NEJM196906052802303