No-D NMR (no-deuterium proton NMR) spectroscopy: a simple yet powerful method for analyzing reaction and reagent solutions.
作者： Thomas R. Hoye , Brian M. Eklov , Troy D. Ryba , Mikhail Voloshin , Letitia J. Yao
DOI: 10.1021/OL049979+
关键词:
摘要: [reaction: see text] The title technique is a convenient and powerful method for directly monitoring or assaying any reaction mixture reagent solution. Examples of some common processes (Fischer esterification, lithiation, butyllithium/THF compatibility, olefin metathesis, quantification assay), each interrogated in its native solvent, are presented. spectral data easy to acquire, the information content makes compelling case routine use No-D NMR spectroscopy.
acs.org
sci-hub.se 参考文章(14)
Martin Nieger, Jan Sültemeyer, Karl Heinz Dötz, Heike Hupfer, Reactions of complex ligands Journal of Organometallic Chemistry. ,vol. 606, pp. 26- 36 ,(1999) , 10.1016/S0022-328X(00)00095-4
Peter Schwab, Robert H. Grubbs, Joseph W. Ziller, Synthesis and Applications of RuCl2(CHR‘)(PR3)2: The Influence of the Alkylidene Moiety on Metathesis Activity Journal of the American Chemical Society. ,vol. 118, pp. 100- 110 ,(1996) , 10.1021/JA952676D
Peter Stanetty, Marko D. Mihovilovic, HALF-LIVES OF ORGANOLITHIUM REAGENTS IN COMMON ETHEREAL SOLVENTS Journal of Organic Chemistry. ,vol. 62, pp. 1514- 1515 ,(1997) , 10.1021/JO961701A
Ivan Keresztes, Paul G. Williard, Diffusion-Ordered NMR Spectroscopy (DOSY) of THF Solvated n-Butyllithium Aggregates Journal of the American Chemical Society. ,vol. 122, pp. 10228- 10229 ,(2000) , 10.1021/JA002278X
M.D. Rausch, D.J. Ciappenelli, Organometallic π-complexes XII. The metalation of benzene and ferrocene by n-butyllithium-N,N,N′,N′-tetramethylethylenediamine Journal of Organometallic Chemistry. ,vol. 10, pp. 127- 136 ,(1967) , 10.1016/S0022-328X(00)81725-8
G. G. Eberhardt, W. A. Butte, A Catalytic Telomerization Reaction of Ethylene with Aromatic Hydrocarbons Journal of Organic Chemistry. ,vol. 29, pp. 2928- 2932 ,(1964) , 10.1021/JO01033A029
S.C. Honeycutt, Kinetics of the cleavage of tetrahydrofuran by n-butyllithium in hydrocarbon solvent Journal of Organometallic Chemistry. ,vol. 29, pp. 1- 5 ,(1971) , 10.1016/S0022-328X(00)87484-7
A. W. Langer, REACTIONS OF CHELATED ORGANOLITHIUM COMPOUNDS* Transactions of the New York Academy of Sciences. ,vol. 27, pp. 741- 747 ,(1965) , 10.1111/J.2164-0947.1965.TB02233.X
John F. McGarrity, Craig A. Ogle, Zdenek Brich, Hans Rudolf Loosli, A rapid-injection (RI) NMR study of the reactivity of butyllithium aggregates in tetrahydrofuran Journal of the American Chemical Society. ,vol. 107, pp. 1810- 1815 ,(1985) , 10.1021/JA00293A002
Michael E Jung, Roberto B Blum, Generation of the enolate of acetaldehyde from non-carbonyl substances and its C-alkylation, O-acylation and O-silylation Tetrahedron Letters. ,vol. 18, pp. 3791- 3794 ,(1977) , 10.1016/S0040-4039(01)83355-4