Synaptogenesis: When Long-Distance Relations Become Intimate

摘要: Neurons in brain talk to each other at synapses which connect neurons into vast communicating synaptic circuits. Synapses are specialized intercellular junctions that diverse and dynamic. The number, locations, distinct functional properties of confer onto circuits an enormous complexity is essential for information processing by these Insight how connections such specified represents a multifaceted problem includes four interrelated questions: 1. How does neuron identify the correct target synapse formation? 2. form on specific parts neuron, e.g., distal dendrites or axon hillocks? 3. decision reached, whether keep discard given after it has been formed? 4. diversity generated controlled? Clearly formation means more than just establishing contacts, specification dynamics types contacts. Although much remains be clarified, available data suggest axonal pathfinding major component specificity, initial fueled mechanisms involve multiple cell adhesion molecules, development use crucial about not survives.