Antioxidant and antimicrobial activity of two standardized extracts from a new Chinese accession of non-psychotropic Cannabis sativa L.
作者： Claudia Muscarà , Antonella Smeriglio , Domenico Trombetta , Giuseppina Mandalari , Erminia La Camera
DOI: 10.1002/PTR.6891
关键词:
摘要: The purpose of this study was to evaluate the antioxidant and antimicrobial properties two extracts from a new Chinese accession (G-309) Cannabis sativa L. (Δ9 -tetrahydrocannabinol <0.2%) with high content propyl side chain phytocannabinoids. Dried flowering tops, as such after hydrodistillation essential oil, were extracted acidic hexane produce extract 1 (CChHE1) 2 (CChHE2), respectively. phytochemical profile CChHE1 CChHE2 investigated by gas chromatography-mass spectrometry (GC-MS) liquid chromatography-diode array detector-electrospray ionization-tandem mass (LC-DAD-ESI-MS/MS) analyses. assessed several in vitro cell-free assays. activity evaluated against Gram-positive Gram-negative bacteria yeast Candida albicans. Phytochemical analyses highlighted cannabidivarinic acid (CBDVA) tetraydrocannabivarinic (THCVA) CChHE1, cannabidivarin (CBDV) tetraydrocannabivarin (THCV) CChHE2. Both showed remarkable strong (MIC 39.06 MBC 39.06-78.13 μg/ml) both ATCC methicillin-resistant clinical strains Staphylococcus aureus. In conclusion, standardized C. could be promising for their possible use novel antibacterial agents treatment widespread S. aureus infections.
sci-hub.st 参考文章(43)
M.A. Prociuk, A.L. Edel, M.N. Richard, N.T. Gavel, B.P. Ander, C.M.C. Dupasquier, G.N. Pierce, Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet. Canadian Journal of Physiology and Pharmacology. ,vol. 86, pp. 153- 159 ,(2008) , 10.1139/Y08-011
Monika Fellermeier, Wolfgang Eisenreich, Adelbert Bacher, Meinhart H. Zenk, Biosynthesis of cannabinoids FEBS Journal. ,vol. 268, pp. 1596- 1604 ,(2001) , 10.1046/J.1432-1327.2001.02030.X
Samir A. Ross, Mahmoud A. ElSohly, The Volatile Oil Composition of Fresh and Air-Dried Buds of Cannabis sativa Journal of Natural Products. ,vol. 59, pp. 49- 51 ,(1996) , 10.1021/NP960004A
P. Mutjé, A. Lòpez, M.E. Vallejos, J.P. López, F. Vilaseca, Full exploitation of Cannabis sativa as reinforcement/filler of thermoplastic composite materials Composites Part A-applied Science and Manufacturing. ,vol. 38, pp. 369- 377 ,(2007) , 10.1016/J.COMPOSITESA.2006.03.009
Chunsheng Gao, Pengfei Xin, Chaohua Cheng, Qing Tang, Ping Chen, Changbiao Wang, Gonggu Zang, Lining Zhao, Diversity analysis in Cannabis sativa based on large-scale development of expressed sequence tag-derived simple sequence repeat markers. PLOS ONE. ,vol. 9, ,(2014) , 10.1371/JOURNAL.PONE.0110638
Monika Fellermeier, Wolfgang Eisenreich, Adelbert Bacher, Meinhart H. Zenk, Biosynthesis of cannabinoids Incorporation experiments with 13C-labeled glucoses European Journal of Biochemistry. ,vol. 268, pp. 1596- 1604 ,(2001) , 10.1046/J.1432-1033.2001.02030.X
Raymond J. M. Niesink, Margriet W. van Laar, Does Cannabidiol Protect Against Adverse Psychological Effects of THC Frontiers in Psychiatry. ,vol. 4, pp. 130- 130 ,(2013) , 10.3389/FPSYT.2013.00130
Marjorie E. Zettler, Grant N. Pierce, Nalini Kaul, Renee Kreml, J. Alejandro Austria, Melanie N. Richard, Andrea L. Edel, Elena Dibrov, Satoru Hirono, A Comparison of Fish Oil, Flaxseed Oil and Hempseed Oil Supplementation on Selected Parameters of Cardiovascular Health in Healthy Volunteers Journal of The American College of Nutrition. ,vol. 27, pp. 51- 58 ,(2008) , 10.1080/07315724.2008.10719674
John M. McPartland, Ethan B. Russo, Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts? Journal of Cannabis Therapeutics. ,vol. 1, pp. 103- 132 ,(2001) , 10.1300/J175V01N03_08
L.G. Zhang, Y. Chang, X.F. Zhang, F.Z. Guan, H.M. Yuan, Y. Yu, L.J. Zhao, Analysis of the genetic diversity of Chinese native Cannabis sativa cultivars by using ISSR and chromosome markers Genetics and Molecular Research. ,vol. 13, pp. 10490- 10500 ,(2014) , 10.4238/2014.DECEMBER.12.10