Transport and Metabolism of Glutamate and Gaba in Neurons and Glial Cells

摘要: Publisher Summary This chapter discusses the important roles of glutamate and gamma-aminobutyric acid (GABA) in brain metabolism. The shows amino acids as excitatory inhibitory transmitters CNS. inactivation these is generally brought about by sodium-dependent high-affinity uptake systems rather than enrymatic degradation. importance different cell types processes characteristics transport are discussed. quantitative GABA into glial cells investigated primary cultures astrocytes that seem to constitute a valid model for such vivo. From studies, it can be concluded quantitatively putative transmitter acids. Whether this has do primarily with pools acids, hence their inactivation, or involved metabolic remains finally elucidated. fact control large surface area around synapses seems favor function acids.On other hand, undoubtedly correct taken up presynaptic nerve endings through processes. In case GABA, even possible distinguish between mechanisms employing inhibitors have been shown selective carriers.