Solid-State Chemistry of Cromolyn Sodium (Disodium Cromoglycate)

摘要: A detailed crystallographic study was made to provide a better understanding and control of processing steps, purity control, dosage formulations cromolyn sodium. The compound, an odorless, white, hydrated crystalline powder, is the disodium salt dibasic acid: 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane. No polymorphs were observed, but crystals can quickly absorb (or lose) water as continuous series interstitial solid solutions. amount absorbed or lost proportional relative humidity environment crystals. At 90% R.H., approaches 24 wt. %, nine molecules per molecule causes lattice expand reversibly, especially in b direction, this results remarkable changes X-ray diffraction pattern, density, other physical properties. Above about 93% compound absorbs more than hold. They then collapse form one two lyotropic mesophases, containing up 260 sodium at 20° 10 %