Overview of hemochromatosis.

摘要: Hemochromatosis is an autosomal recessive genetic disorder that occurs with high prevalence in populations of European origin. The gene abnormal hemochromatosis found on the short arm chromosome 6 close proximity (approximately 1 centimorgan) to HLA-A, but product coded for by unknown. pathogenetic mechanism continued, excessive absorption dietary iron loss normal control mechanisms, leading a gradual vast expansion storage as ferritin and especially hemosiderin. Through mechanisms probably include peroxidation lipid membranes, excess injures hepatocytes, islet B cells, gonadotropes anterior pituitary, myocardium, synovial chondrocytes, other cells tissues well. Most patients remain undiagnosed throughout life. Removal phlebotomy will prevent all complications when begun early significantly improve survival virtually patients. It important, therefore, diagnosis be considered much more frequently clinical medicine order this effective therapy utilized.