Primary involvement of pharynx and peyer's patch in inhalational and intestinal anthrax.

摘要: Bacillus anthracis causes three forms of anthrax: inhalational, gastrointestinal, and cutaneous. Anthrax is characterized by both toxemia, which caused secretion immunomodulating toxins (lethal toxin edema toxin), septicemia, associated with bacterial encapsulation. Here we report that, contrary to the current view B. pathogenesis, spores germinate establish infections at initial site inoculation in inhalational cutaneous without needing be transported draining lymph nodes, that inhaled infection nasal-associated lymphoid tissues. Furthermore, found Peyer's patches mouse intestine are primary growth after intragastric inoculation, thus establishing an animal model gastrointestinal anthrax. All routes progressed spleen, lungs, ultimately blood. These discoveries were made possible through development a novel dynamic using bioluminescent non-toxinogenic capsulated bacteria can visualized within real-time, demonstrate value vivo imaging analysis infection. Our data imply previously unrecognized portals entry demand more intensive investigation, will significantly transform perception pathogenesis.