Results of small intestinal bacterial overgrowth testing in irritable bowel syndrome patients: clinical profiles and effects of antibiotic trial.
作者： M Majewski , R W McCallum
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摘要: Purpose Small intestinal bacterial overgrowth (SIBO) may coexist with irritable bowel syndrome (IBS) and eradication therapy has been reported as effective in reducing IBS symptoms. Aims of this study were to: (1) Assess the clinical profiles patients, who underwent breath testing a glucose substrate--glucose test (GBT); (2) Evaluate hydrogen methane parameters various groups; (3) role inhibition gastric acid contributing to SIBO; (4) Investigate efficacy safety non-absorbable antibiotic rifamixin for symptom relief. Methods 204 patients met ROME II criteria (170F & 34M; mean age 46.4; range 18-88) GBT. 8 these positive GBT treated rifaximin 200 mg, 4 times day 1 month assessments repeated. Results 93 (46%) had 68 (73%) IBS-diarrhea dominant (IBS-D), 12 (13%) constipation (IBS-C) 13 (14%) alternating pattern. 48% SIBO receiving PPI compared 40% negative 61 (66%) produced only hydrogen, 27 (29%) only, 5 (5%) both-hydrogen methane. There more producers IBS-C then IBS-D group (58% vs 28%) while formers (71% 42%). (7F IM; 55, 31-85) received 800 mg/day. Repeat was normal 6 (75%), patient (12.5%) normalized according but remained positive. Symptoms score improved 7 (87.5%) no adverse events noted. Conclusions present nearly half large cohort based on results GBT; Chronic use not associated Methane are likely be constipated; Rifaximin is treatment controlled trials warranted.
advms.pl 参考文章(16)
Danial E Baker, Rifaximin: a nonabsorbed oral antibiotic. Reviews in Gastroenterological Disorders. ,vol. 5, pp. 19- 30 ,(2005)
G.R. Corazza, M.G. Menozzi, A. Strocchi, L. Rasciti, D. Vaira, R. Lecchini, P. Avanzini, C. Chezzi, G. Gasbarrini, The diagnosis of small bowel bacterial overgrowth: Reliability of jejunal culture and inadequacy of breath hydrogen testing Gastroenterology. ,vol. 98, pp. 302- 309 ,(1990) , 10.1016/0016-5085(90)90818-L
S. D. Wexner, E. D. Ehrenpreis, J. M. N. Jorge, The lactulose hydrogen breath test as a measure of orocaecal transit time European Journal of Surgery. ,vol. 160, pp. 409- 416 ,(1994)
Henry C. Lin, Small Intestinal Bacterial Overgrowth JAMA. ,vol. 292, pp. 852- 858 ,(2004) , 10.1001/JAMA.292.7.852
Gregg W. Van Citters, Henry C. Lin, Management of small intestinal bacterial overgrowth. Current Gastroenterology Reports. ,vol. 7, pp. 317- 320 ,(2005) , 10.1007/S11894-005-0025-X
C. WILLIAMS, K. E. L. McCOLL, Review article: proton pump inhibitors and bacterial overgrowth. Alimentary Pharmacology & Therapeutics. ,vol. 23, pp. 3- 10 ,(2006) , 10.1111/J.1365-2036.2006.02707.X
Mark Pimentel, Henry C. Lin, Pedram Enayati, Brian van den Burg, Hyo-Rang Lee, Jin H. Chen, Sandy Park, Yuthana Kong, Jeffrey Conklin, Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 290, ,(2006) , 10.1152/AJPGI.00574.2004
Mark Pimentel, Evelyn J. Chow, Henry C. Lin, Normalization of Lactulose Breath Testing Correlates With Symptom Improvement in Irritable Bowel Syndrome: A Double-Blind, Randomized, Placebo-Controlled Study The American Journal of Gastroenterology. ,vol. 98, pp. 412- 419 ,(2003) , 10.1111/J.1572-0241.2003.07234.X
e. m. m. quigley, b. flourie, Probiotics and irritable bowel syndrome: a rationale for their use and an assessment of the evidence to date. Neurogastroenterology and Motility. ,vol. 19, pp. 166- 172 ,(2007) , 10.1111/J.1365-2982.2006.00879.X
E. C. LAURITANO, M. GABRIELLI, A. LUPASCU, A. SANTOLIQUIDO, G. NUCERA, E. SCARPELLINI, F. VINCENTI, G. CAMMAROTA, R. FLORE, P. POLA, G. GASBARRINI, A. GASBARRINI, Rifaximin dose-finding study for the treatment of small intestinal bacterial overgrowth. Alimentary Pharmacology & Therapeutics. ,vol. 22, pp. 31- 35 ,(2005) , 10.1111/J.1365-2036.2005.02516.X