[Haplotype and linkage analysis of HLA-I classical genes in Chinese Han population].

摘要: The aim of this study was to investigate the parameters gene frequencies, haplotype frequencies and linkage disequilibrium HLA-A, -B, -Cw in HLA classical I loci for Chinese Han population. HLA-B HLA-Cw were genotyped 1014 unrelated China people using low resolution PCR-SSP typing method, their genetic analyzed by statistic methods. results indicated that among all detected HLA-I genes, A*02 (0.33), A*11 (0.24), B*15 (0.14), B*13 (0.13), Cw*03 (0.25) Cw*07 (0.18) popular groups distributing population, A*02-B*46 (0.071), A*11-B*15 (0.051), A*02-Cw*01 (0.084), A*11-Cw*03 (0.079), B*46-Cw*01 (0.095) B*13-Cw*03 (0.071) predominant haplotypes Additionally, A*02-B*46, A*30-B*13, A*30-Cw*06, A*02-Cw*01, B*58-Cw*03 statistically significant with strong disequilibrium. While A*02-B*15, A*02-B*40, A*24-Cw*03, A*02-Cw*03 A*31-Cw*03 disequilibrium, them A*24-Cw*03 appeared frequently recombination events. In addition, A*02-B*46-Cw*01 (0.075), A*30-B*13-Cw*06 (0.046), A*11-B*13-Cw*03 (0.045), A*33-B*58-Cw*03 (0.044), A*11-B*15-Cw*08 (0.027), A*02-B*38-Cw*07 (0.023) A*11-B*40-Cw*07 (0.022) main extended conclusions, investigated systematically polymorphism features which may provide useful researches colonial evolution, clinical transplantation disease susceptibility.