Global gene expression profiles of hematopoietic stem and progenitor cells from patients with chronic myeloid leukemia: the effect of in vitro culture with or without imatinib
作者： Sócrates Avilés‐Vázquez , Antonieta Chávez‐González , Alfredo Hidalgo‐Miranda , Dafne Moreno‐Lorenzana , Lourdes Arriaga‐Pizano
DOI: 10.1002/CAM4.1187
关键词:
摘要: In this study, we determined the gene expression profiles of bone marrow-derived cell fractions, obtained from normal subjects and Chronic Myeloid Leukemia (CML) patients, that were highly enriched for hematopoietic stem (HSCs) progenitor (HPCs) cells. Our results indicate CML HSCs HPCs closer to progenitors, whereas showed most different profile all. We found marrow each other than those marrow. The major biologic processes dysregulated in cells included DNA repair, cycle, chromosome condensation, adhesion, immune response. also genomic changes both under culture conditions, several genes involved steroid biosynthesis, segregation upregulated, transcription regulation apoptosis downregulated. Interestingly, these same, regardless addition Imatinib (IM) culture. Finally, identified three genes-PIEZO2, RXFP1, MAMDC2- are preferentially expressed by primitive encode membrane proteins; thus, they could be used as biomarkers
sci-hub.se 参考文章(54)
Jonathan M. Gerber, Jessica L. Gucwa, David Esopi, Meltem Gurel, Michael C. Haffner, Milada Vala, William G. Nelson, Richard J. Jones, Srinivasan Yegnasubramanian, Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations. Oncotarget. ,vol. 4, pp. 715- 728 ,(2013) , 10.18632/ONCOTARGET.990
Mark D. Long, Patrick R. van den Berg, James L. Russell, Prashant K. Singh, Sebastiano Battaglia, Moray J. Campbell, Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity Nucleic Acids Research. ,vol. 43, pp. 7330- 7348 ,(2015) , 10.1093/NAR/GKV642
Boris Kovacic, Andrea Hoelbl, Gabriele Litos, Memetcan Alacakaptan, Christian Schuster, Katrin M. Fischhuber, Marc A. Kerenyi, Gabriele Stengl, Richard Moriggl, Veronika Sexl, Hartmut Beug, Diverging fates of cells of origin in acute and chronic leukaemia Embo Molecular Medicine. ,vol. 4, pp. 283- 297 ,(2012) , 10.1002/EMMM.201100208
Hideo Kuniba, Koh-ichiro Yoshiura, Tatsuro Kondoh, Hirofumi Ohashi, Kenji Kurosawa, Hidefumi Tonoki, Toshiro Nagai, Nobuhiko Okamoto, Mitsuhiro Kato, Yoshimitsu Fukushima, Tadashi Kaname, Kenji Naritomi, Tadashi Matsumoto, Hiroyuki Moriuchi, Tatsuya Kishino, Akira Kinoshita, Noriko Miyake, Naomichi Matsumoto, Norio Niikawa, Molecular karyotyping in 17 patients and mutation screening in 41 patients with Kabuki syndrome Journal of Human Genetics. ,vol. 54, pp. 304- 309 ,(2009) , 10.1038/JHG.2009.30
Kolja Eppert, Katsuto Takenaka, Eric R Lechman, Levi Waldron, Björn Nilsson, Peter van Galen, Klaus H Metzeler, Armando Poeppl, Vicki Ling, Joseph Beyene, Angelo J Canty, Jayne S Danska, Stefan K Bohlander, Christian Buske, Mark D Minden, Todd R Golub, Igor Jurisica, Benjamin L Ebert, John E Dick, Stem cell gene expression programs influence clinical outcome in human leukemia Nature Medicine. ,vol. 17, pp. 1086- 1093 ,(2011) , 10.1038/NM.2415
Alessandra Marini, Giovanni Carulli, Antonio Azzarà, Bruno Grassi, Fabio Ambrogi, Serum Cholesterol and Triglycerides in Hematological Malignancies Acta Haematologica. ,vol. 81, pp. 75- 79 ,(1989) , 10.1159/000205530
Harald Herrmann, Irina Sadovnik, Sabine Cerny-Reiterer, Thomas Rülicke, Gabriele Stefanzl, Michael Willmann, Gregor Hoermann, Martin Bilban, Katharina Blatt, Susanne Herndlhofer, Matthias Mayerhofer, Berthold Streubel, Wolfgang R. Sperr, Tessa L. Holyoake, Christine Mannhalter, Peter Valent, Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia. Blood. ,vol. 123, pp. 3951- 3962 ,(2014) , 10.1182/BLOOD-2013-10-536078
TL Holyoake, X Jiang, MW Drummond, AC Eaves, CJ Eaves, Elucidating critical mechanisms of deregulated stem cell turnover in the chronic phase of chronic myeloid leukemia Leukemia. ,vol. 16, pp. 549- 558 ,(2002) , 10.1038/SJ.LEU.2402444
Brian J Druker, Perspectives on the development of imatinib and the future of cancer research Nature Medicine. ,vol. 15, pp. 1149- 1152 ,(2009) , 10.1038/NM1009-1149
Yoshiro Maru, Molecular biology of chronic myeloid leukemia Cancer Science. ,vol. 103, pp. 1601- 1610 ,(2012) , 10.1111/J.1349-7006.2012.02346.X