Diffusive mass transport coefficients are not constant during a single exchange in continuous ambulatory peritoneal dialysis.

摘要: Mass transport coefficients usually are assumed to be constant during single 6 hr exchanges of dialysis fluid in continuous ambulatory peritoneal (CAPD). To check this assumption, the authors estimated diffusive mass coefficients, KBD, for five low molecular weight solutes 34 dwell studies with glucose 3.86% (20 studies), 2.27% (nine and 1.36% studies) fluids time periods 3-30, 30-60, 60-90, 90-120, 120-180, 180-240, 240-360 min. Dialysate volume rate reabsorption were measured using radiolabeled serum albumin (RISA) as a marker. Convective was described sieving coefficient 0.55 all solutes. The KBD values sodium, but higher at beginning (3-30 min) than end (180-360 by an average approximately 50% urea, creatinine, glucose, 120% potassium three fluids. This initial increment did not depend upon concentration fluid, except urea. steady state value reached 120 min patterns well exponential decay function, 0.02 min-1. similar electrically neutral solutes, different electrolytes. increments mean that clearances short (30-60 may 5-15% calculated from values.