Arachidonic acid-stimulated platelet tests: Identification of patients less sensitive to aspirin treatment

摘要: Serum thromboxane-B2 (TxB2), together with arachidonic acid (AA)-induced platelet aggregation, are, at the moment, most used tests to identify patients displaying high on-aspirin treatment reactivity (HAPR). Both are specific for aspirin action on cyclooxygenase-1. While correlation between serum TxB2 assay and clinical outcome is established, data conflicting regard a possible association AA-stimulated markers outcome. To understand such discrepancy, we performed retrospective study compare both assays. We collected from 132 receiving daily dose of (100 mg/day) 48 alternate days. All Patients who received were studied AA-induced aggregation levels formation was also in 71 out entire population. Consistent recommendations literature, defined HAPR by setting cut-off point 3.1 ng/ml thromboxane B2 20% aggregation. According this point, divided our overall population into two groups: (1) ng/ml. found low agreement HAPR. Our results show that >20% smaller number comparison TxB2. A good acid-induced production (r = 0.76619).