α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release

作者: Siqin Luo , Jennifer M. Kulak , G. Edward Cartier , Richard B. Jacobsen , Doju Yoshikami

DOI: 10.1523/JNEUROSCI.18-21-08571.1998

关键词:

摘要: … of α-conotoxin AuIB, we tested it at 75 μm, 100-fold the IC 50 for the α3β4 nAChR. As shown in Figure 4B, α-conotoxin AuIB is at least 100 times more potent on α3β4 than on all other α/…

参考文章(28)
J.M. McIntosh, D. Yoshikami, E. Mahe, D.B. Nielsen, J.E. Rivier, W.R. Gray, B.M. Olivera, A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI. Journal of Biological Chemistry. ,vol. 269, pp. 16733- 16739 ,(1994) , 10.1016/S0021-9258(19)89452-8
G. Edward Cartier, Doju Yoshikami, William R. Gray, Siqin Luo, Baldomero M. Olivera, J. Michael McIntosh, A new α-conotoxin which targets α3β2 nicotinic acetylcholine receptors Journal of Biological Chemistry. ,vol. 271, pp. 7522- 7528 ,(1996) , 10.1074/JBC.271.13.7522
Michele Zoli, Clément Léna, Marina R. Picciotto, Jean-Pierre Changeux, Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice The Journal of Neuroscience. ,vol. 18, pp. 4461- 4472 ,(1998) , 10.1523/JNEUROSCI.18-12-04461.1998
E. X. Albuquerque, E. X. Albuquerque, E. F. R. Pereira, J. M. Mcintosh, M. Alkondon, Alpha-conotoxin-ImI: a competitive antagonist at alpha-bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons. Journal of Pharmacology and Experimental Therapeutics. ,vol. 278, pp. 1472- 1483 ,(1996)
Anna A Penn, Patricio A Riquelme, Marla B Feller, Carla J Shatz, Competition in Retinogeniculate Patterning Driven by Spontaneous Activity Science. ,vol. 279, pp. 2108- 2112 ,(1998) , 10.1126/SCIENCE.279.5359.2108
H Sershen, A Balla, A Lajtha, E.S Vizi, Characterization of nicotinic receptors involved in the release of noradrenaline from the hippocampus Neuroscience. ,vol. 77, pp. 121- 130 ,(1997) , 10.1016/S0306-4522(96)00425-3
Jennifer S. Martinez, Baldomero M. Olivera, William R. Gray, A. Grey Craig, Duncan R. Groebe, Stewart N. Abramson, J. Michael McIntosh, alpha-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry. ,vol. 34, pp. 14519- 14526 ,(1995) , 10.1021/BI00044A030
William G. Conroy, Darwin K. Berg, Neurons Can Maintain Multiple Classes of Nicotinic Acetylcholine Receptors Distinguished by Different Subunit Compositions Journal of Biological Chemistry. ,vol. 270, pp. 4424- 4431 ,(1995) , 10.1074/JBC.270.9.4424
Francesco E. Pontieri, Gianluigi Tanda, Francesco Orzi, Gaetano Di Chiara, Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs Nature. ,vol. 382, pp. 255- 257 ,(1996) , 10.1038/382255A0
Catherine Rapier, George G. Lunt, Susan Wonnacott, Stereoselective nicotine-induced release of dopamine from striatal synaptosomes: concentration dependence and repetitive stimulation. Journal of Neurochemistry. ,vol. 50, pp. 1123- 1130 ,(1988) , 10.1111/J.1471-4159.1988.TB10582.X