Modified plasma-derived lipoproteins in human atherosclerotic plaques
作者： M. Shaikh , S. Martini , J.R. Quiney , P. Baskerville , A.E. La Ville
DOI: 10.1016/0021-9150(88)90011-1
关键词:
摘要: Low density lipoproteins extracted from surgical specimens of human atherosclerotic plaques (A-LDL) showed altered electrophoretic mobility indicating a greater negative charge than that plasma LDL (P-LDL). A-LDL but not P-LDL high affinity binding/degradation by monocyte-derived macrophages; this was inhibited acetylated native P-LDL. Following injection 125I-labelled autologous prior to reconstructive arterial surgery, polyacrylamide and agarose gel electrophoresis intima the its apolipoprotein B moiety were derived P-LDL; product The compositions intermediate lipoprotein (A-IDL) differed those obtained (P-IDL) A-IDL reduced triglyceride content increased esterified unesterified cholesterol. Although total cholesterol similar P-LDL, there an increase in decrease cholesteryl ester. These studies indicate plaque is modified vivo. Compared with differences composition, associated binding acetyl receptor macrophages.
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