Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits

摘要: The present disclosure is directed to compositions and methods which utilize the tetracycline scaffold, preferably scaffold of or minocycline, significantly lack antibiotic activity. compounds have neuroprotective attributes without interfering with drugs capacity pass through blood brain barrier. These activity because their inhibition neuronal cell cycle progression. are characterized in part by a fifth ring joining positions 9 10.