Human monoclonal antibodies to the cd4-binding domain of hiv, uses thereof and synergistic neutralization of hiv

摘要: Human monoclonal antibodies specific for the CD4-binding domain of HIV gp120 are useful in neutralization and prevention infection treatment a subject infected with HIV. Such heterohybridomas producing them disclosed. Synergistic mixtures at least two human different epitopes used to neutralize HIV, prevent treat In this synergistic mixture, one antibody has broad group specificity, is preferably domain. The other V3 loop range neutralizing activity such that it neutralizes virus MN strain, MN-like families, widely divergent HIV-1 isolates which members various lop classes.