Planar Chirality − Synthesis and Transformations of 8‐ to 10‐Membered Heterocycles Bearing (E)‐Olefins

摘要: Medium-sized heterocycles (8-membered to 10-membered) are prevalently found in organic chemistry as key intermediates the synthesis of more complex structures or core natural products pharmaceutically important compounds. At present, production such rings remains a challenge synthesis. During past decade, an increasing amount interest has focused on generation cyclic lactones and peptides, well hairpins β-turn mimics, medium-sized were thought represent suitable fragments. Furthermore, heterocyclic this type characteristic range products, total these is broad field for chemists test new strategies develop methods. The aim review discus some modern synthesizing unsaturated 8- 10-membered heterocycles, with scope restricted ring systems incorporating N, O, S function combination (E)-olefins. planar-chiral properties thus induced have been exploited further stereoselective regioselective reactions. Although number conversions described only simple without complicated stereogenic properties, most them seem offer undiscovered potential terms syntheses. However, emphasis methods processes. subdivided into two major chapters: ring-closure ring-enlargement reactions, additional information given cycloadditions fragmentations.