Detection of circulating tumor necrosis factor after endotoxin administration.

摘要: Abstract Cytokines, products of stimulated macrophages, are thought to mediate many host responses bacterial infection, but increased circulating cytokine concentrations have not been detected consistently in infected patients. We measured plasma tumor necrosis factor alpha (cachectin), interleukin-1β, and gamma interferon, together with physiologic hormonal responses, 13 healthy men after intravenous administration Escherichia coli endotoxin (4 ng per kilogram body weight) during a control period saline administration. Eight additional subjects received ibuprofen before receiving or saline. Plasma levels were generally less than 35 pg milliliter throughout the period, 90 180 minutes mean peak 240±70 milliliter, as compared 35±5 Host temporally associated in...