Protracted intravenous fluorouracil infusion with radiation therapy in the management of localized pancreaticobiliary carcinoma: a phase I Eastern Cooperative Oncology Group Trial.
作者： R Whittington , D Neuberg , W J Tester , A B Benson , D G Haller
DOI: 10.1200/JCO.1995.13.1.227
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摘要: PURPOSEThe purpose of this study was to determine the maximum-tolerated dose (MTD) fluorouracil (5-FU) administered as a protracted intravenous (IV) infusion with concurrent radiation in patients pancreaticobiliary carcinoma.METHODSTwenty-five recurrent, residual, or unresectable carcinoma pancreas biliary tract were treated on phase I trial IV infusions 5-FU, beginning at 200 mg/m2/d, therapy (59.4 Gy 33 fractions over 6 7 weeks). Chemotherapy began first day and continued through entire course treatment. After each cohort five had been observed, daily escalated 25-mg/m2 increments until dose-limiting toxicity encountered. An additional MTD. Clinical examination computed tomography (CT) used evaluate response patterns progression.RESULTSThe MTD 5-FU 250 mg/m2/d. The toxic...
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