A novelty seeking phenotype is related to chronic hypothalamic-pituitary-adrenal activity reflected by hair cortisol.

摘要: Reduced hypothalamic pituitary adrenal (HPA) activity is associated with greater novelty seeking in humans. Hair cortisol represents an integrated proxy measure of total production/release over extended period time and may be a valuable tool for tracking the HPA system. Sampling approaches (collection blood, saliva, urine, or feces) socially housed nonhuman primates present number technical challenges collection particularly when repeated sampling necessary. Herein we describe relationship between levels measured hair collected from 230 female vervet (Chlorocebus aethiops sabaeus) monkeys free-choice phenotype. A predator-like object was placed at periphery outdoor enclosures 30 min speed approach (latency to within 1 m) persistence interest (number 1 min intervals were scored. composite Novelty Seeking score, combining these two measures, calculated. The intra-class correlation coefficient (ICC = .68) different objects across years indicated that this score reflects stable aspect temperament. samples each subject approximately 3–6 months following second assessment; determined hair. significant inverse level (p < .01) noted. high groups had significantly lower scores than low both (p's < .05). These results suggest average promote seeking, while inhibit behavior.