Sympathetic interactions of AT1 receptors

摘要: The present chapter deals with the interaction between renin-angiotensin system (RAS) and sympathetic nervous (SNS). Numerous studies have shown that (locally produced) angiotensin II (Ang II), main effector of RAS, can enhance transmission. Ang has been to ganglionic transmission, facilitate NA release from synaptic nerve terminals, block uptake, synthesis, postsynaptic effects noradrenaline. Angiotensin-Converting enzyme (ACE) inhibitors AT1 receptor blockers attenuate facilitating effect on neurotransmission. It is generally believed exerts its neurotransmission through activation receptors. Several new, non-peptidergic AT1-selective are now available. potency these drugs respect attenuation facilitation by subject in several studies, discussed chapter. In some order regarding this sympatho-inhibition differs inhibition direct pressor II. These findings suggest differences affinity for pre- receptor. Sympatho-inhibition a class antagonists. conditions which plays pathophysiological role, such as hypertension congestive heart failure, property may well be therapeutic relevance.