Insights from graph theory on the morphologies of actomyosin networks with multilinkers.

摘要: Quantifying the influence of microscopic details on dynamics development overall structure a filamentous network is important in number biologically relevant contexts, but it not obvious what order parameters can be used to adequately describe this complex process. In paper we investigated role multivalent actin-binding proteins (ABPs) reorganizing actin filaments into higher-order networks via computer model semiflexible filaments. We characterize importance local connectivity among filaments, as well global features actomyosin networks. first map graph representations and then, using principles from network-theory parameters, combine properties these gain insight heterogeneous morphologies at level. find that ABPs with valency greater than 2 promote filament bundles large clusters much extent bivalent multilinkers. also show active myosinlike motor formation dendritic branches stalk bundles. Our work motivates future studies embrace theory tool detected by experiments, leading quantitative understanding manipulating self-assembly unique architectures underlie structural scaffold cell relating its mobility shape.