Plasma Endothelin-1 Levels in Obese Hypertensive and Normotensive Men

摘要: Plasma endothelin-1 (ET-1) levels were studied in 15 obese hypertensive (mean age 48.5 ± 3.9 years) and normotensive men 49.5 3.6 before after weight loss due to an 800 kcal/day diet lasting 12 weeks. Circulating peptide concentrations also assessed nonobese ( n = 11) 12). Baseline plasma ET-1 similar (0.87 0.22 pg/ml) (0.91 0.30 pg/ml). In seven men, caloric restriction normalized blood pressure (systolic: from 166.6 8.1 145.0 6.3 mmHg, P 2 , 8), not by despite a significant decrease of BMI (from 0.83 0.23 0.60 0.16 pg/ml, r 0.518, 0.535, 0.558, 0.596,