Formulation and characterization of palm oil esters based nano- cream for topical delivery of piroxicam
作者： Muthanna F Abdulkarim , Ghassan Zuhair Abdullah , Mallikarjun Chitneni , Elrashid Saleh Mahdi , Mun Fei Yam
DOI: 10.5138/IJDD.2010.0975.0215.02040
关键词:
摘要: Palm oil esters are high molecular weight that has been newly synthesized by University Putra Malaysia researchers. It received a lot of attention for its pharmaceutical and chemical application. Piroxicam is nonsteroidal anti-inflammatory drug with analgesic antipyretic activity. low solubility in water as well Log P value 1.8. Generally, drugs more than 0.5 needed to be formulated into modified dosage form. One these formulations nano sized cream. Hence, the ability formulating tricky dispersed system questionable. The aim this study investigate palm phase formulation piroxicam O/W nano-cream. Three points were selected from prepared pseudoternary diagram different Tween Span mixtures. partition coefficient external was detected. Rheological properties, droplet size, structural properties zeta potential dispersion containing measured. cream formed size measurement TEM less 100 nm. could concluded suitable nano-cream piroxicam. Keywords: esters; Solubility; coefficient; Rheology; Surface
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