Nr-CAM gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors

作者: Anil Sehgal , Gerald P. Murphy , Alton L. Boynton

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摘要: The present invention relates to the identification of a novel role Nr-CAM in cell transformation and aberrant cellular proliferation. In particular, altered gene expression number primary tumors lines derived from tumors, addition to, ligands for Nr-CAM. Further, relates, part, Applicants' surprising discovery that inhibition or activity transformed cells reverses phenotype.

参考文章(12)
W. Michael Flanagan, Antisense comes of age Cancer and Metastasis Reviews. ,vol. 17, pp. 169- 176 ,(1998) , 10.1023/A:1006098218335
Holmlund Jt, Monia Bp, Dorr Fa, Kwoh Tj, Toward antisense oligonucleotide therapy for cancer: ISIS compounds in clinical development. Current Opinion in Molecular Therapeutics. ,vol. 1, pp. 372- ,(1999)
S. T. Crooke, Basic Principles of Antisense Therapeutics Handbook of experimental pharmacology. ,vol. 131, pp. 1- 50 ,(1998) , 10.1007/978-3-642-58785-6_1
C. Frank Bennett, Kevin P. Anderson, Brenda Baker, Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2 ,(1996)
G. Schwab, I. Duroux, C. Chavany, C. Hélène, E. Saison-Behmoaras, An approach for new anticancer drugs:Oncogene-targeted antisense DNA Annals of Oncology. ,vol. 5, pp. 55- 58 ,(1994) , 10.1093/ANNONC/5.SUPPL_4.S55
Andrea D. Branch, A good antisense molecule is hard to find Trends in Biochemical Sciences. ,vol. 23, pp. 45- 50 ,(1998) , 10.1016/S0968-0004(97)01155-9
Robert E. Sobol, Mark R. Green, Ernest S. Kawasaki, Detection of carcinoma metastases by nucleic acid amplification ,(1994)
Olga Matveeva, Brice Felden, Scott Audlin, Raymond F Gesteland, John F Atkins, A Rapid in vitro Method for Obtaining RNA Accessibility Patterns for Complementary DNA Probes: Correlation with an Intracellular Pattern and Known RNA Structures Nucleic Acids Research. ,vol. 25, pp. 5010- 5016 ,(1997) , 10.1093/NAR/25.24.5010