The Renin-Angiotensin-Aldosterone System in Cardiovascular Diseases

摘要: Angiotensin II and aldosterone have both beneficial deleterious effects that affect the function of cardiovascular system (blood vessels heart), kidneys other organs. The history discoveries aldosterone, molecules inhibit their synthesis or antagonize receptors, is an excellent example translational research. Indeed, a series experiments been determinant to initiate clinical studies, conversely, some unexpected secondary observed in treated patients understood by experimental This chapter will describe functions renin-angiotensin-aldosterone progression ideas which allowed introduce most successful drugs used hypertension heart failure.