RAGE: A Receptor with a Taste for Multiple Ligands and Varied Pathophysiologic States

摘要: Publisher Summary This chapter focuses on the functions and properties of immunoglobulin super family molecule receptor for advanced glycation end products (RAGE) that interacts with different ligands exhibits varied consequences cellular functions, depending physiologic or pathophysiologic setting. In diabetes, RAGE binds nonenzymatically glycated adducts macromolecules termed endproducts (AGEs), resulting in perturbation multiple properties. Alzheimer's disease represents a situation which expression increases dramatically. Amyloid- β peptide (A β) , is thought to be critical pathogenesis neurodegeneration, another ligand RAGE. present occasional cortical neurons normal brain, spinal motor stained intensely The binding amphoterin—also RAGE—to not mediated by AGEs, but determinants protein backbone. Peripheral nerves also demonstrate diabetic neuropathy. Under conditions when engages A result stress, and, certain cases such as it leads cytotoxicity.