Relationship of bispectral index values, haemodynamic changes and recovery times during sevoflurane or propofol anaesthesia in rabbits.

摘要: Summary The aim of this study was to determine and compare the degree hypnosis achieved during propofol or sevoflurane anaesthesia in rabbits using bispectral index (BIS), evaluate its usefulness as a predictor both haemodynamic changes recovery times. Twenty adult male New Zealand White rabbits, average weight 4.470.4 kg, were used for study. Animals randomly allocated one two groups with 10 rabbits/group. An electroencephalographic recording obtained from each conscious rabbit prior drug administration. All animals received buprenorphine preanaesthetic medication (0.05 mg/kg, intravenous [i.v.]). Anaesthesia induced (8 i.v.) all animals; maintained via inhalation (1 minimum alveolar concentration – end-tidal 3.7% at fresh gas flow rate 3 L/ min; group I), i.v. (0.6 mg/kg/min; II). orotracheally intubated spontaneous ventilation throughout (100% oxygen). After abdominal surgery through ventral midline laparotomy, allowed recover anaesthesia. Cardiovascular variables BIS values recorded intervals procedure, duration In groups, mean significantly decreased immediately after induction, compared baseline consciousness. Anaesthetic depth (evaluated by clinical observation) similar groups; however, II had higher (Po0.001) 30 s before incision until discontinued. There no significant difference 1 5 min either group. During administration, correlations found between arterial blood pressure (MABP), heart (HR). Mean discontinuation administration anaesthetic agent greater (69.176.0) than I (49.372.2). However, longer (38.477.2 min) (11.572.5 min). conclusion, can be differentiate unconscious states rabbits. derived an electroencephalogram end not useful predicting speed propofol-anaesthetized undergoing surgery. Despite correlation